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Science

Mechanisms, platforms, and the research that matters.

Coronal brain section at a resection cavity with neurons and residual tumour in contrasting colours, synaptic puncta on the cavity rim, and a hydrogel lining the void

Science 25 Aug 2026

What tumour–neuron synapses mean for glioblastoma — and why a local siRNA gel is the proposed answer

A 25 August Nature Biomedical Engineering paper shows malignant synapses concentrated at the GBM–brain interface, then tests an intracavitary TrkB-silencing hydrogel that more than doubled median survival in a mouse resection model.

Medical-illustration schematic of a torso with ectopic bone threading through muscle planes and a magnified inset of Activin A blocked at the ACVR1 receptor

Science 19 Aug 2026

What blocking Activin A means for FOP — Regeneron’s Pasatru and a disease that turns muscle into bone

FDA approved garetosmab on 19 August as the first FOP drug shown, in a placebo-controlled trial, to cut both new heterotopic-ossification lesions (by ≥90%) and clinician-assessed flare-ups.